GPSuc: Global Prediction of Generic and Species-specific Succinylation Sites by aggregating multiple sequence features
نویسندگان
چکیده
منابع مشابه
A systematic identification of species-specific protein succinylation sites using joint element features information
Lysine succinylation, an important type of protein posttranslational modification, plays significant roles in many cellular processes. Accurate identification of succinylation sites can facilitate our understanding about the molecular mechanism and potential roles of lysine succinylation. However, even in well-studied systems, a majority of the succinylation sites remain undetected because the ...
متن کاملPosition-Specific Analysis and Prediction of Protein Pupylation Sites Based on Multiple Features
Pupylation is one of the most important posttranslational modifications of proteins; accurate identification of pupylation sites will facilitate the understanding of the molecular mechanism of pupylation. Besides the conventional experimental approaches, computational prediction of pupylation sites is much desirable for their convenience and fast speed. In this study, we developed a novel predi...
متن کاملAccurate in silico identification of species-specific acetylation sites by integrating protein sequence-derived and functional features
Lysine acetylation is a reversible post-translational modification, playing an important role in cytokine signaling, transcriptional regulation, and apoptosis. To fully understand acetylation mechanisms, identification of substrates and specific acetylation sites is crucial. Experimental identification is often time-consuming and expensive. Alternative bioinformatics methods are cost-effective ...
متن کاملGeneric features of quinone-binding sites.
Introduction: generic features of quinone-binding sites (Q sites) Quinones form a central link between protein complexes in most types of electron-transfer chain. More than 50 distinct types of Q site associated with respiratory and photosynthetic electron-transfer complexes have been identified to date. Most involve rather loose and dynamic binding of quinone, and for these Q sites inhibitory ...
متن کاملPrediction of Protein Kinase Specific Phosphorylation Sites with Multiple SVMs
The protein phosphorylation is one of the important processes in the cell signaling pathway. A variety of protein kinase families are involved in this process, and each kinase family phosphorylates different kinds of substrate proteins. Many methods to predict the kinase-specific phosphoryrated sites or different types of phosphorylated residues (Serine/Threonine or Tyrosin) have been developed...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLOS ONE
سال: 2018
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0200283